We are creating the next generation of biologic agonists for the remittive treatment of severe inflammatory and immune diseases

  • Most cellular processes are controlled by interactions between protein molecules, often protein clusters with defined geometry 
  • Traditional therapeutic design is ‘one target molecule – one therapeutic binding interaction’, or two-to-one for antibodies
  • But most cellular processes involve the simultaneous interaction between several or many protein molecules, or coordinated clusters of receptors that enhance signaling 
  • Therapeutic modalities that can present motifs for binding to multiple target partners present next-generation opportunities
  • Our proprietary computational methods are creating novel protein therapeutics that engage their targets through carefully coordinated, avid binding interactions that induce potent agonist responses
  • We are creating the next generation of biologic agonists for the remittive treatment of severe inflammatory and immune diseases

Novel Protein Therapeutic NanoCages

    Proprietary technology allows the design of fully human nanoparticles with targeted presentation geometries and sequence composition to deliver potent therapeutics
  • Architecture, avidity and dosing control agonism
  • Rapid optimization of NanoCages using AI for I&I
  • Avid display of targeted payloads with ideal geometry for potent activity
  • Superior thermal stability, rigidity, and manufacturability of scaffolds
  • We are creating the next generation of biologic agonists for the remittive treatment of severe inflammatory and immune diseases

Enables rational drug design for challenging targets

  • Most cellular proteins are too small to study by cryo EM.  <50kD
  • New strategy developed to use protein cages as large and symmetric scaffolds
  • Modular design allows for rigid binding of small to medium protein cargos and potentially GPCRs
  • Structure determination reveals cargo structure and drug complexes
  • Successful imaging at < 3 Å for SM discovery
  • We are partnering with pharma and biotech companies to enable structure determination and small molecule therapeutic design